Menene dihydrofolate reductase ke yi?
Menene dihydrofolate reductase ke yi?
Anonim

Dihydrofolate reductase, ko DHFR, wani enzyme ne wanda ke rage dihydrofolic acid zuwa tetrahydrofolic acid, ta amfani da NADPH a matsayin mai ba da gudummawar lantarki, wanda za'a iya canza shi zuwa nau'in tetrahydrofolate cofactors da ake amfani da su a cikin 1-carbon transfer chemistry. A cikin mutane, da DHFR An shigar da enzyme ta hanyar DHFR gene.

Hakazalika, an tambayi, menene DHFR kuma me yasa yake da mahimmanci?

Dihydrofolate Reductase (DHFR) sosai muhimmanci enzyme saboda yana samar da cofactors waɗanda suke da mahimmanci don haɗin DNA. THF wani muhimmin cofactor ne da ke da hannu wajen canja wurin ƙungiyoyin methyl, methylene, da formyl daga wannan kwayoyin zuwa wani yayin samar da nucleotides da amino acid da yawa.

Daga baya, tambaya ita ce, wadanne kwayoyi ke hana dihydrofolate reductase? Pyrimethamine kuma trimethoprim su ne mafi yawan amfani da dihydrofolate reductase inhibitors.

A nan, menene aikin dihydrofolate reductase a cikin kwayoyin cuta?

Dihydrofolate reductase wani karamin enzyme ne wanda ke taka rawar tallafi, amma muhimmiyar rawa, a cikin ginin DNA da sauran matakai. Yana kula da yanayin folate, ƙwayar ƙwayar cuta mai ɓarna wanda ke jujjuya ƙwayoyin carbon zuwa ga enzymes da suke bukatar su a cikin halayensu.

Ta yaya methotrexate ke tsoma baki tare da DHFR?

Don ciwon daji, methotrexate gasa ya hana dihydrofolate reductase (DHFR), wani enzyme wanda ke shiga cikin haɗin tetrahydrofolate. Dangantakar da methotrexate domin DHFR yana kusan ninki 1000 na folate. Har ila yau, folate yana da mahimmanci ga purine da pyrimidine tushe biosynthesis, don haka kira so a hana.

Shahararren taken